Clinical observation of Fisher-Evans Syndrome

Abstract

A brief literature review is given on a rare disease - Fisher-Evans syndrome (combination of immune hemolytic anemia and immune thrombocytopenic purpura). The clinical observation of this disease from the personal practice of the authors is demonstrated. The disease was diagnosed in a patient with high comorbidity who had undergone lymphogranulomatosis (cured). Initially, the disease debuted with immune thrombocytopenia (ITP), therapy with glucocorticoids and rituximab did not lead to a positive effect. Remission of ITP was achieved only after splenectomy. Thrombocytopenia no longer recurred. But five years later, a severe hemolytic crisis developed. High doses of glucocorticoids managed to stop the hemolytic crisis, but complete remission of immune hemolytic anemia was achieved after rituximab therapy.